Author/Editor		Kos-Golja, Mojca; Budihna, Nataša V; Batagelj, Igor
Title		Long term follow-up after radiosynovectomy with yttrium 90 in patients with different rheumatic diseases
Translated title		Radiosinoviektomija z itrijem 90 pri bolnikih z različnimi revmatskimi boleznimi: ugotavljanje trajanja terapevtskega učinka
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 31, št. 4
Publication year		1997
Volume		str. 353-7
Language		eng
Abstract		The aim of the retrospective study was to evaluate the efficacy of radiosynovectomy (with yttrium 90) mainly in patients with rheumatoid arthritis, less with some other rheumatic diseases. The evaluation period varied from half to nine years. The procedure was performed in 273 patients (225 females, 48 males) or in 463 joints (402 knees, 61 shoulders and ankles). The effects was evaluated by change in degree of morning stiffiness, pain and swelling (score from 0 to 9). Very good results were obtained in 69 (15%), good in 142 (30.5%), moderate in 197 (42.5%) and no effect in 55 (12%) joints. Six months after the procedure 38 joints (8%), half to two years after 221 joint (48%) were in good remission, after 3 to 4 years 95 joints (20%), after 5 to 6 years 57 joints (12%) were well, 7 to 9 years later 52 joints (11%) showed no signs of arthritis. Joint pain and swelling were the most frequent procedure complications (5.6%). In two patients with additional immunomodulating therapy chronic myeloid and lymphocityc leukaemia were diagnosed. Radiosynovectomy is considered to be an effective and safe treatment for synovitis indifferent rheumatic diseases.
Summary		Cilj retrospektivne študije je bil oceniti učinek izotopske sinovektomije z itrijem 90 predvsem pri bolnikih z revmatoidnim artritisom inmanj z nekaterimi revmatičnimi boleznimi. Bolnike smo opazovali v obdobju od pol do devet let. Poseg je bil napravljen pri 273 bolnikih (225 žensk, 48 moških) oziroma na 463 sklepih (402 na kolenih, 61 na ramenih in gležnjih). Učinek smo ocenjevali s spremembo stopnje jutranje okorelnosti , bolečine in otekline sklepa (od 0 do 9). Zelo dobre rezulate smo dosegli na 69 (15%), dobre na 142 (30,5%), srednje dobre na 197 sklepih (42,5%), na 55 sklepih ni bilo učinka (12%). Pol leta po posegu je bilo 38 sklepov (8%) v remisiji, pol do dve leti 221 (48%), po 3 do 4 letih 95 (20%), po 5 do 6 letih je bilo 57 sklepov brez znakov vnetja (12%), po 7 do 9 letih pa še 52 (11%). Najpogostejši zapleti po sinovektomiji so bile bolečine in otekline sklepov (5,6%). Pri dveh bolnicah, ki sta dobivali tudi imunomodulirajoča zdravila, smo odkrili kronično mieloično oziroma limfatično levkemijo. Izotopska sinovektomija je torej učinkovito in varno zdravljenje sinovitisa pri različnih boleznih.
Descriptors		ARTHRITIS, RHEUMATOID SYNOVIAL MEMBRANE YTTRIUM RADIOISOTOPES FOLLOW-UP STUDIES