Author/Editor		Bren, A; Guček, A
Title		Which antimicrobial agent in CAPD peritonitis?
Type		članek
Source		Antiinfective drugs and chemotherapy
Vol. and No.		Letnik 15, št. 1
Publication year		1997
Volume		str. 29-33
Language		eng
Abstract		In this retrospective study we analyzed the efficacy of first choice antimicrobial modalities in 191 cases of peritonitis in patients on continuous ambulabory peritoneal dialysis (CAPD). The most frequent isolates from peritoneal effluent were staphylococci, Acinetobacter, corynebacteria and streptococci, rarely E coli, Pseudomonas, Klebsiella and others. The initially used antimicrobials were: combination of gentamicin and methicillin, gentamicin and cloxacillin, mezlocillin and clinidamycin or monotherapy with cefazolin, ciprofloxacin, pefloxacin, and ofloxacin. Antimicrobials were initially administered in loading dose and afterwards in maintenance, mostly intraperitoneally, ciprofloxacin and pefloxcin also intravenously and orally, ofloxacin only orally. The duration of treatment averaged from 10 to 12 days. The efficacy of first choice antimicrobials was 76% (13/17) in gentamicin and methicillin combination, in gentamicin and cloxacillin 93% (13/14), in mezlocillin and clindamycin 88% (15/17), in cefazolin 73% (30/41), in ciprofloxacin 74% (49/66), in pefloxacin 78% (14/18), and in ofloxacin 67% (12/18). We concluded that at least initial intraperitoneal application of antimicrobials with broad spectrum activity against Gram-positive and Gram-negative microbes expressed the highest percentage of efficacy as first choice treatment.
Descriptors		PERITONEAL DIALYSIS, CONTINUOUS AMBULATORY PERITONITIS ANTIBIOTICS, COMBINED RETROSPECTIVE STUDIES DIALYSIS SOLUTIONS GENTAMICINS METHICILLIN CLOXACILLIN MEZLOCILLIN CLINDAMYCIN CEFAZOLIN CIPROFLOXACIN PEFLOXACIN OFLOXACIN TREATMENT OUTCOME