Author/Editor		Kandus, Aljoša; Malovrh, Marko; Bren, Andrej F
Title		Influence of blood flow on adsorption of beta2-microglobulin onto AN69 dialyzer membrane
Type		članek
Source		Artif Organs
Vol. and No.		Letnik 21, št. 8
Publication year		1997
Volume		str. 903-6
Language		eng
Abstract		Adsorption onto the dialyzer membrane is a contributiong factor to the elimination of beta 2-microglobulin (beta 2M) from the sera of uremic patients. The purpose of this prospective study was to ascertain the influence of the blood flow rate on adsorption of beta 2M onto the polycrylonitrile (AN69) hollow-fiber dialyzer membrane in 8 patients during regular hemodialysis (HD). Blood first passed through a low-flux polysulfone dialyzer and then through an AN69 dialyzer, which was not in contact with the dialysis fluid. During the investigation period (first hour of the HD session), the bloodflow rate was 100 ml/min (fist part of the study), 200 ml/min (second part of the study), and 300 ml/min (third part of the study). Ultrafiltration was not performed during the investigation period. At the start of the HD sessions, the serum concentration of beta 2M in the afferent blood line did not differ significantly among the 3 parts of the study. Serum beta 2M was measured in samples taken from the afferent and efferent blood lines of the AN69 dialyzer at 5, 10, 15, 30, 45, and 60 min. The serum beta 2M concentration decreased significantly in blood that had passed through the AN69 dialyzer. This decrease, indicating membrane adsorption, was maximal during the first part and minimal during the third part of study. THe decrease in the contact time between the blood and the AN69 could be the underlying cause. The calculated quantities of beta 2M absorbed onto the AN69 membrane (44.2 +- 102.2, 43.2 +- 12.1, and 42.6 +- 17.3 mg) did not differ significantly among the 3 parts of the study. These results suggest that an increase in blood flow rate from 100 to 3000 ml/min did not significantly affect the quantity of beta 2M absorbed onto the AN69 membrane.
Descriptors		HEMODIALYSIS MEMBRANES, ARTIFICIAL BETA 2-MICROGLOBULIN BIOCOMPATIBLE MATERIALS ACRYLIC RESINS ACRYLONITRILE ADSORPTION BLOOD FLOW VELOCITY BLOOD PROTEINS HEMATOCRIT POLYMERS SULFONES UREMIA PROSPECTIVE STUDIES