Author/Editor		Kalan, Gorazd
Title		Farmakokinetika glukoza-1-fosfata u liječenju hipofosfatemije umjetno ventilirane nedonoščadi s hijalinomembranskom bolešću
Translated title		Pharmacokinetics of glucose-1-phosphate in premature babies with idiopathic respiratory distress syndrome in substitutional therapy of hypophosphatemia
Type		monografija
Place		Zagreb
Publisher		Sveučilište u Zagrebu, Medicinski fakultet
Publication year		1996
Volume		str. 51
Language		cro
Abstract		Introduction: An adequate input of phosphorus and calcium is of vital importance for the growth and development of a new-born. Hypophosphatemia is especially frequent in critically ill premature babies and presents an important clinical problem. Aims of the study: ( 1 ) to find out the incidence of hypophosphatemia in critically ill premature babies, (2) to compare efficiency of parenteral to enteral substitution of phosphate by glucose-1-phosphate, (3) to evaluate the recommended dose and the dosing interval of glucose-1-phosphate, (4) to register eventual adverse effects of glucose-1-phosphate in treatment of hypophosphatemia. Patients and methods: Every critically ill premature baby was determined the serum concentration of inorganic phosphate immediately after admission to the intensive care unit. Glucose-1-phosphate pharmacokinetics was investigated in 24 mechanically ventilated premature hypophosphatemic babies with idiopathic respiratory distress syndrome, ranging from 30 to 37 weeks of gestational age and from 1.5 to 2.9 kg of birth weight. Hypophosphatemia was defined when the level of serum inorganic phosphate was below 2.1 mmol/L. The premature babies included in the study were randomised into two groups. The group A babies (n = l5) were given glucose-1-phosphate intravenously, whereas the group B babies (n = 9) were given glucose-1-phosphate enterally through a nasogastric tube, always in the same dose of 1 mmol/kg. After the application of glucose-1-phosphate we traced serum concentration of inorganic phosphate and ionised calcium and their excretion in 24-hour urine. Results: The incidence of hypophosphatemia in critically ill premature babies was 84%. Normophosphatemia was reached after enteral application of glucose- 1-phosphate through a nasogastric tube (serum inorganic phosphate concentration 21 mmol/L). (Abstracts truncated at 2000 characters)
Descriptors		HYALINE MEMBRANE DISEASE HYPOPHOSPHATEMIA PHOSPHATES RESPIRATION, ARTIFICIAL INFANT, NEWBORN RESPIRATORY DISTRESS SYNDROME INFANT, PREMATURE INFUSIONS, PARENTERAL INTUBATION, GASTROINTESTINAL INTENSIVE CARE UNITS, NEONATAL GESTATIONAL AGE BIRTH WEIGHT