Author/Editor		Beović, Bojana
Title		Sodobno sistemsko zdravljenje glivičnih okužb
Translated title		Contemporary systemic antifungal treatment
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 37, št. Suppl 1
Publication year		1998
Volume		str. 55-72
Language		slo
Abstract		Modern antifungal agents and approaches used in systemic treatment of fungal infections are reviewed. Amphotericin B still plays a major role in the treatment of invasive fungal infections. In some cases it may be replaced by its less toxic lipid formulations. Newer azoles, fluconazole and itraconazole have become another treatment possibility in management of invasive fungal infections. Fluconazole is recommended in treatment of invasive candidiasis in stable patients. Intraconazole has been used successfully in some cases of invasive aspergillosis. Fluconazole and itraconazole are the most important systemic drugs in treatment of mucosal candidiasis. Newer drugs such as itraconazole, fluconazole and terbinafine are easy to administer and successful in treatment of skin infections caused by dermatophytes.
Summary		Pregledni članek obravnava zdravila in sobodne pristope, ki jih uporabljamo pri sistemskem zdravljenju glivičnih okužb. Invazivne glivične okužbe zdravimo najpogosteje z amfotericinom B. V nekaterih primerih običajno obliko zdravila zaradi neuspešnosti ali toksičnosti nadomestimo z lipidnimi pripravki. V zadnjem času sta se uveljavila dva novejša azolna antimikotika. Flukonazol lahko pri stabilnih bolnikih uporabljamo za zdravljenje invazivnih oblik kandidiaze, uspešen je tudi pri zdravljenju kandidiaze sečil. Intrakonazol uporabljamo v posameznih primerih za zdravljenje invazivne aspergiloze. Flukonazol in itrakonazol sta se uveljavila pri zdravljenju kandidiaze sluznic. Kožne glivične okužbe z dermatofiti zaradi dobrih farmakokinetičnih lastnosti vedno pogosteje zdravimo z itrakonazolom, flukonazolom in terbinafinom.
Descriptors		MYCOSES ANTIFUNGAL AGENTS AMPHOTERICIN B FLUCONAZOLE ITRACONAZOLE FLUCYTOSINE