Author/Editor		Mlačak, Blaž; Kapš, Peter; Piletič, Milivoj; Ivka, Branimir
Title		Fibrogen, dejavniki tveganja in zastopanost periferne arterijske okluzivne bolezni pri sladkornih bolnikih
Translated title		Fibrinogen, risk factors and prevalence of the peripheral arterial occlusive disease by diabetics
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 67, št. 3
Publication year		1998
Volume		str. 139-41
Language		slo
Abstract		Background. Recent epidemiologic studies have ascertained that the firbrinogen level is a significant risk factor for the development of atherosclerosis. Our research object was to find out the occurrence frequency of the heightened fibrinogen level and known risk factors for atherosclerosis in a group of diabetics. Furthermore, we intended to find out the occurrence frequency of the peripheral arterial occlusive disease in persons with risk factors. Methods. In the test group there were 138 diabetics at te age of 23 to 88, and among them 60 men and 78 women. The control group which consisted of 160 examinees without diabetes, among them 69 men and 91 women, was comparable to the test group age, sex and vocational pretentiousness. Menacing factors were defined by knowncriteria, while we considered the fibrinogen level in blood over 3.0 g/L as heightened. The peripheral arterial occlusive disease on lower limbs was ascertained by the systolic blood pressure measuring by means of the supersonic Doppler detector. The difference in the menacing factors participation for atherosclerosis, and the heightened fibrinogen level between the test and the control group was tested by the c square test. Results. The peripheral arterial occlusive disease was found in 27.3% of diabetics, and in 8.8% of examinees in the control group. The difference is statistically significant (P<0.001). 52.2% of diabetics had the heightened fibrinogen level, 84.5% of the increased body weight, 65.5% of hypertension, and 76.4% of hyperlipidemia (cholesterol and triglycerides together). In the test group there was in comparison with the control group a significantly greater number of persons with the heightened fibrinogen level (P<0.001), hyperlipidemia (P<0.01), hypertension (P<0.01), and the increased body weight (P<0.05). (Abstract truncated at 2000 characters.)
Summary		Izhodišča. Novejše epidemiološke raziskave ugotavljajo, da je raven fibrinogena pomemben dejavnik tveganja za razvoj ateroskleroze. Cilj naše raziskave je bil ugotoviti pogostost pojavljanja zvišane ravni fibrinogena in poznanihdejavnikov tveganja za aterosklerozo pri skupini sladkornih bolnikov. nadalje smo želeli ugotoviti pogostost pojavljanja periferne arterijske okluzivne bolezni pri osebah z dejavniki tveganja. Metode. V testni skupini je bilo 138 slakodrnih bolnikov med 23. in 88. letom starosti, od tega 60 moških in 78 žensk. kontrolna skupina, ki je imela 160 preiskovancev brez diabetesa, od tega 69 moških in91 žensk, je bila primerljiva s testno po starosti, spolu in zahtevnosti poklica. Dejavnike ogrožanja smo definirali po znanih kriterijih, medtem ko smo raven fibrinogena v krvi nad 3,0 g/L imeli za zvišano. Periferno arterijsko okluzivno bolezen na spodnjih udih smo ugotavljali z merjenjem sistoličnega krvnega tlaka s pomočjo ultrazvočnega Dopplerjevega detektorja. Razliko v zastopanosti dejavnikov ogrožanja za aterosklerozo in zvečane ravni fibrinogena med tesno in kontrolno skupino smo testirali s testom hi-kvadrat. Rezultati. periferno arterijsko okluzivno bolezen smo ugotovili pri 27,3% diabetikov in pri 8,8% preiskovancev v kontrolni skupini. Razlika je statistično pomembna (P<0,001). 52,2% diabetikov je imelo zvišano raven fibrinogena, 84,5% zvečano telesno težo, 65,5% hipertenzijo in 76,4% hiperlipidemijo (holesterol in trigliceridi skupaj. V testni skupini je bilo v primerjavi s kontrolno skupino pomembno večje število oseb, ki so imele zvišaneo raven fibrinogena (P<0,001), hiperlipidemijo )P<0,01), hipetenzijo (P<0,01) in zvečano telesno težo (P<0,05). Zaključki. Raziskava kaže, da je zvišana raven fibrinogena prisotna pri diabetikih, zlasti še pri tistih bolnikih, ki imajo sočasno periferno arterijsko okluzivno bolezen.(Izvleček prekinjen pri 2000 znakih.)
Descriptors		DIABETES MELLITUS ARTERIAL OCCLUSIVE DISEASES FIBRINOGEN RISK FACTORS ULTRASONOGRAPHY, DOPPLER