Author/Editor		Kansky, A; Kristl, J
Title		Importance of epidermal lipids for proper functioning of the stratum corneum barrier
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 7, št. 1
Publication year		1998
Volume		str. 3-8
Language		eng
Abstract		Proper structure of stratum corneum (SC) is important for regulation ofvital biologic functions as are protection from penetration of foreign substances through the skin, protection from UV rays, abnormal transepidermal water loss (TEWL), protecion from injuries, or smooth shedding of corneocytes. Two systems, the epidermal lipids (interstitial lipids of SC) and the corneocyte cell envelopes (CE) are primarily responsible for the so-called barrier function. Lipids reach the SC through the secretion of lammelar (Odland) bodies situated in the granular layer, while the CE are being formed from loricrin, involucrin as well as from other protein precursors. Barrier function is impaired in a number of skin disorders, e.g. chronic eczema, atopic dermatitis, ichthyses, aged skin as well as in others. Clinical tests in humans and animal experiments are teaching us that the barrier function may be restored more quickly by applying ointments and creams containing adequate mixtures of lipids.
Descriptors		EPIDERMIS MEMBRANE LIPIDS SEBACEOUS GLANDS SEBUM LIPIDS SPHINGOLIPIDS STEROLS ICHTHYOSIS