Author/Editor		Cimperman, Jože
Title		Zgodnja nevroborelioza in klopni meningoencefalitis: klinične značilnosti in posledice
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1997
Volume		str. 110
Language		slo
Abstract		For more than 50 years tick-borne meningoencephalitis (TBE) has been known in Slovenia and has been endemic in geographically well defined regions of the country, while Lyme borreliosis (LB) has been known in the country for more than 10 years. THe two diseases are endemic in Slovenia, and the regions coincide. Since they have the same carrier, the tick Ixodes ricinus, a concomitant infection with TBE virus and Borrelia burgdorferi (B. burgdorferi) sensu lato is possible. We performed a prospective study comprising 272 patients with lymphocytic meningitis or meningoencephalitis who were treated on our clinic in the years 1993 and 1994. The patients were assigned into 5 groups with regard to the inclusion criteria for TBE infection and LB. The firts group comprised 111 patients (40.8%) with TBE, the second group comprised 36 patients (13.2%) with proven borrelial infection, the third group comprised 65 patients (23.9%) with well established concomitant infection, the fourth group comprised 15 patients (5.5%) with suspected borrelial infection and the fifth group comprised 45 patients (16.6%) with a double infection, the borrelial infection having been suspected. In one patient we isolated B. burgdorferi sensu lato from the liquor and proved the presence of RNA of TBE virus, using PCR method. 83.3% of patients from the group with well established borrelial infection met the criteria for neuroborreliosis; 53.8% came from the group with established double infection, 60.0% from the group of patients with suspected borrelial infection and 11.1% of patients with double infection, in whom borrelial infection was suspected (the patients from the last two groups met the clinical criteria for neuroborreliosis, only). We have observed that a concomitant infection with B. burgdorferi sensu lato and TBE virus in regions endemic for the two diseases is more frequent than first supposed.(Abstract truncated at 2000 characters.)
Descriptors		LYME DISEASE ENCEPHALITIS, TICK-BORNE NERVOUS SYSTEM DISEASES BORRELIA BURGDORFERI ENCEPHALITIS VIRUSES, TICK-BORNE CEREBROSPINAL FLUID ANTIBODIES, BACTERIAL ANTIBODIES, VIRAL