Author/Editor		Kikelj, Danijel; Pečar, Slavko; Kotnik, Vladimir; Štalc, Anton; Wraber-Herzog, Branka; Simčič, Saša; Ihan, Alojz; Klampfer, Lidija; Povšič, Lučka; Grahek, Rok; Suhadolc, Elizabeta; Hočevar, Mirjam; Hoenig, Helmut; Rogi-Kohlenprath, Renate
Title		N-(trans-2-((2'-(acetylamino)cyclohexyl)oxy)acetyl)-L-alanyl-D-glutamic acid: a novel immunologically active carbocyclic muramyl dipeptide analogue
Type		članek
Source		J Med Chem
Vol. and No.		Letnik 41, št. 4
Publication year		1998
Volume		str. 530-9
Language		eng
Abstract		A novel non-pyrogenic carbocyclic muramyl dipeptide (MDP) analogue, N-(trans-2-((2'-(acetylamino)cyclohexyl))oxy)acetyl)-L-analyl-D-glutamic acid, was obtained by replacement of the N-acetylmuramic acid part and the D-isoglutamine residue of the MDP molecule by a trans-2-((2'-(acetylamino)cyclohexy))oxy))acetyl moiety and D-glutamic acid, respectively. The title compound was selected as a promising candidate for further evaluation among several related analugues on the basis of an immunorestoration test in mice. This novel nor-MDP analogue protects mice against the immunosuppressive effect of cyclophamide and increases the nonspecific resistance of mice against fungal infection. It is an immunomodulator which enhances the maturation of lymphocytes B to plasma cells and increases the activity of lymphocytes B and lymphocytes T as well as that of macrophages but does not alter the number of these cells.
Descriptors		ACETYLMURAMYL-ALANYL-ISOGLUTAMINE B-LYMPHOCYTES MACROPHAGES PLASMA CELLS T-LYMPHOCYTES MICE ADJUVANTS, IMMUNOLOGIC CYCLOPHOSPHAMIDE IMMUNE TOLERANCE LYMPHOCYTE TRANSFORMATION MODELS, MOLECULAR SPLEEN STEREOISOMERISM