Author/Editor     Kveder, Marina; Pifat, Greta; Pečar, Slavko; Schara, Milan
Title     The influence of lower alcohols on the surface lipid monolayer in LDL
Type     članek
Source     Croat Chem Acta
Vol. and No.     Letnik 71, št. 1
Publication year     1998
Volume     str. 189-98
Language     eng
Abstract     Interaction of methanol, ethanol, propanol and butanol with human plasma low density lipoproteins (LDL) was stuied in this work. The surface lipid monolayer of LDL was spin labeled an the electron spin resonance (ESP) spectra were measured in the presence and absence of alcohols. The decomposition of the complex ESR spectra was performed via theoretical simulatoins of experimental data. The results gained from this study indicate that the influence of alcohol could be observed through the changes of lipid ordering in the surface of LDL monolayer. This observation supports the hypothesis on the mechanism of alcohol action through its interference with lipid-protein interactions at the level of macromolecular surface.
Descriptors     LIPOPROTEINS, LDL
ALCOHOL, METHYL
ALCOHOL, ETHYL
ALCOHOL, PROPYL
ALCOHOLS, BUTYL
SPIN LABELS
ELECTRON SPIN RESONANCE SPECTROSCOPY