Author/Editor | Podlesek, Zdravko; Herzog, Blagajana; Comino, Aleksandra | |
Title | Amplification of bacitracin transporter genes in the bacitracin producing Bacillus licheniformis | |
Type | članek | |
Source | FEMS Microbiol Lett | |
Vol. and No. | Letnik 157 | |
Publication year | 1997 | |
Volume | str. 201-5 | |
Language | eng | |
Abstract | We have amplified the previously cloned and sequenced genes of the bacitracin exporter (bcr), a member of the ATP-binding transport protein family, within the chromosome of the bacitracin producing Bacillus licheniformis. Amplification of the transporter genes was followed by greatly increased bacitracin resistance. Antibiotic production was enchanced at a low level of bcr genes amplification. An enlarged increase in the copy number of the bcr genes negatively affects the overall growth of bacteria. | |
Descriptors | BACILLUS BACITRACIN ABC TRANSPORTERS GENE EXPRESSION REGULATION, BACTERIAL DRUG RESISTANCE, MICROBIAL GENES, BACTERIAL CLONING, MOLECULAR BIOLOGICAL TRANSPORT PLASMIDS |