Author/Editor     Podlesek, Zdravko; Herzog, Blagajana; Comino, Aleksandra
Title     Amplification of bacitracin transporter genes in the bacitracin producing Bacillus licheniformis
Type     članek
Source     FEMS Microbiol Lett
Vol. and No.     Letnik 157
Publication year     1997
Volume     str. 201-5
Language     eng
Abstract     We have amplified the previously cloned and sequenced genes of the bacitracin exporter (bcr), a member of the ATP-binding transport protein family, within the chromosome of the bacitracin producing Bacillus licheniformis. Amplification of the transporter genes was followed by greatly increased bacitracin resistance. Antibiotic production was enchanced at a low level of bcr genes amplification. An enlarged increase in the copy number of the bcr genes negatively affects the overall growth of bacteria.
Descriptors     BACILLUS
BACITRACIN
ABC TRANSPORTERS
GENE EXPRESSION REGULATION, BACTERIAL
DRUG RESISTANCE, MICROBIAL
GENES, BACTERIAL
CLONING, MOLECULAR
BIOLOGICAL TRANSPORT
PLASMIDS