Author/Editor		Popović-Hadžija, Marijana; Poljak-Blaži, Marija
Title		Differential expression of Bcl-2 protein in non-irradiated or UVC-irradiated murine myleoid leukaemia (ML) cells
Translated title		Razlika v ekspresiji proteina Bcl-2 v mieloidno leukemičnih celicah pri obsevanih miših z ultravijoličnimi žarki in pri neobsevanih miših
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 32, št. 1
Publication year		1998
Volume		str. 47-52
Language		eng
Abstract		In this work, we examined the expression of Bcl-2 protein in myueloid leukaemia (ML) cells and the effect of UVC-light on the expression level. The protein of bcl-2 oncogene was detected by immunocytochemical method. In spleen cells of healthy RFM donors was detected 34.3% of Bcl-2 positive cells. When leukaemia came to the non terminal phase (NTP) more than 50% of cells expressed this protein. However, in terminal phase (TP) of leukaemia growth, only 24.4% Bcl-2 positive cells was determined. After UVC irradiation, the expression of Bcl-2 protein was significantly higher in spleen cells of healthy donors. However, UVC light did not change the expression of Bcl-2 in cells of both investigated phases of ML growth. Bcl-2 protein may be involved in the resistance of ML cells to UVC light.
Descriptors		LEUKEMIA, MYELOID ULTRAVIOLET RAYS PROTO-ONCOGENE PROTEINS C-BCL-2 MICE GENES, BCL-2 SPLEEN