Author/Editor		Fležar, Margareta; Lavrenčak, Jaka; Žganec, Mario; Us-Krašovec, Marija
Title		Longitudinal study of malignancy associated changes in progressive cervical dysplasia
Translated title		Sledenje MAC (malignancy-associated changes) pri bolnicah s progresivnimi displazijami materničnega vratu
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 32, št. 1
Publication year		1998
Volume		str. 65-9
Language		eng
Abstract		Eight of 29 patients with progressive CIN were followed for 2 to 10 years. Their consecutive Pap smears were destained and stained according to Feulgen thionin method. Cyto-Savant/TM high resolution image cytometer (Oncometrics Technol. Corp., Vancouver, Canada) was used for image acquisition and analysis. Average values of nuclear texture features and their probability distributions for consecutive Pap smears from each patient were calculated. Three out of 5 discriminant MAC, highDNAamount, highDNAcomp and highDNAarea, were to increase as a function of time in 5 out of 8 patients. A preliminary analysis which was performed on non-standardized archival material demonstrated a monotonous increase of discrete texture features as a function of time in patients with progressive CIN.
Descriptors		CERVIX DYSPLASIA IMAGE CYTOMETRY CELL NUCLEUS DNA