Author/Editor | Maeder, Karsten | |
Title | Monitoring drug release and polymer erosion from therapeutically used biodegradable drug carriers by EPR and MRI in vitro and in vivo | |
Translated title | Ugotavljanje sproščanja zdravil in erozije polimerov s tehnikami EPR in MRI iz biološko razgradljivih prenašalcev zdravil | |
Type | članek | |
Source | Radiol Oncol | |
Vol. and No. | Letnik 32, št. 1 | |
Publication year | 1998 | |
Volume | str. 89-94 | |
Language | eng | |
Abstract | The in vivo performance of anticancer drugs is very often limited by their poor bioavailability, serious side effects and short half lives. During the last years, biodegradable drug carriers have been developed to overcome these problems. Despite the clinical use of these delivery systems, there is a rather poor understanding of the detailed mechanisms of drug release and polymer erosion, particularly in vivo. The paper demonstrates how nonivasive magnetic resonance techniques ESR and MRI may contribute to increase our understanding of the in vivo fate of biodegradable drug delivery systems. | |
Descriptors | ANTINEOPLASTIC AGENTS DRUG CARRIERS DRUG DELIVERY SYSTEMS BIODEGRADATION MAGNETIC RESONANCE IMAGING ELECTRON SPIN RESONANCE SPECTROSCOPY |