Author/Editor		Poredoš, Pavel
Title		Etiopatogeneza ateroskleroze
Translated title		Pathogenesis of atherosclerosis
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 37, št. Suppl 3
Publication year		1998
Volume		str. 1-11
Language		slo
Abstract		The development of the atherosclerotic process is reviewed together with the typical morphological changes in the vessel wall, and the mechanisms triggering atherosclerosis. Among several hypotheses on the development of atherosclerosis the most plausible one remains the over 100-year old hypothesis of endothelial injury as the initiating event, which is followed by lipid deposition and deposition of other plasma components in the arterial wall. The advanced atherosclerotic process involves in addition to the intima also the deeper arterial wall layers.An advanced atherosclerotic plaque is often complicated by thrombosis on the uneven surface of the plaque. In recent years the prevailing opinion that atherosclerosis is primarily a degenerative process has been challenged by the view that it is in fact an inflammatory process in the arterial wall. The inflammation is either a response to injury or to infection by bacteria or viruses. The fibrinolytic system has an important role in thromboembolic complications of atherosclerosis, but it may also be one of the etiopathogenetic factors in atherosclerosis.
Summary		V prispevku je opisan razvoj aterosklerotičnega procesa, najznačilnejše spremembe v sestavi žilne stene ter mehanizmi, ki sodelujejo pri nastanku in razvoju ateroskleroze. Avtor navaja, da je od različnih možnih razlag za nastanek ateroskleroze še vedno najverjetnejša tista, ki je stara že več kot 100 let in ki kot najvažnejši in prvi dogodek navaja poškodbo endotelija, ki ji sledi odlaganje lipidov in drugih sestavin plazme v žilno steno. Tak proces lahko prizadene tudi globlje plasti arterije, napredovale aterosklerotične spremembe se neredko zapletejo tudi z nastankom krvnega strdka na površini neravne aterosklerotične lehe. Več desetletij prevladujoče mnenje, da je ateroskleroza primarno degenerativni proces, so v zadnjih letih nadomestile razlage, da gre najverjetneje za vnetno dogajanje v arterijski steni. Do vnetja naj bi prišlo kot odgovor na poškodbo, morda pa je primarni dogodek okužba z določenimi bakterijami ali virusi. Opisana je tudi vloga fibrinolitičnega sistema pri nastanku trombemboličnih zapletov, fibrinolitični sistem pa je opredeljen kot eden od možnih etiopatogenetskih dejavnikov ateroskleroze.
Descriptors		ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR FOAM CELLS CHOLESTEROL LIPOPROTEINS INFLAMMATION INFECTION FIBRINOLYSIS