Author/Editor     Stegnar, Mojca; Božič, Mojca
Title     Pomen homocisteina pri razvoju žilnih bolezni
Translated title     The role of homocysteine in the development of vascular disease
Type     članek
Source     Med Razgl
Vol. and No.     Letnik 37, št. Suppl 3
Publication year     1998
Volume     str. 69-74
Language     slo
Abstract     A moderately increased level of homocysteine in blood is a risk factor for premature coronary heart disease, peripheral arterial occlusive disease, cerebrovascular disease and probably also venous thromboembolic disease. Homocysteine is increased due to genetic causes or due to deficiency of cofactors (vitamins B6, B12 and folate) acting in the homocysteine metabolism. Hyperhomocysteinemia is diagnosed by measuring total fasting homocysteine concentration or by measuring homocysteine concentration affer loading with methionine. The role of homocysteine in development of vascular disease in not completely understood, but endothelial injury is presumably the central event. Homocysteine can be reduced by treatment with B6, B12, folate and betaine. However, the efficacy of such treatment in the primary and secondary prevention of vascular disease has to be established.
Summary     Zmerno povišana koncentracija homocisteina v krvi je dejavnik tveganja za prezgodnji razvoj koronarne srčne bolezni, okluzivne bolezni perifernih arterij, cerebrovaskularne bolezni in verjetno tudi venske trombembolijske bolezni. Vzroki za zmerno hiperhomocisteinemijo so dedni ali pridobljeni zaradi pomanjkanja kofaktorjev (vitaminov B6, B12 in folata), ki sodelujejo pri presnovi homocisteina. Hiperhomocisteinemijo prepoznamo z merjenjem celokupne koncentracije homocisteina v krvi na tešče ali po obremenitvi z metioninom. Mehanizmov, po katerih homocistein vpliva na razvoj žilne bolezni, ne poznamo dobro, verjetno pa je osrednji dogodek poškodba endotelija. Raven homocisteina lahko znižujemo z dajanjem vitaminov B6, B12, folata in betaina, vendar pa za enkrat še ni znana njihova učinkovitost pri primarnem in sekundarnem preprečevanju žilne bolezni.
Descriptors     VASCULAR DISEASES
HOMOCYSTEINE
ARTERIAL OCCLUSIVE DISEASES
THROMBOEMBOLISM