Author/Editor		Peterlin, Borut; Petrovič, Danijel; Milanez, Tomaž
Title		Pomen nekaterih genetskih polimorfizmov za razvoj ateroskleroze
Translated title		The role of the genetic polymorphisms in the process of atherosclerosis
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 37, št. Suppl 3
Publication year		1998
Volume		str. 75-83
Language		slo
Abstract		Atherosclerosis is a model of multifactorial disorders. Various genetic polymorphisms of different candidate genes are implicated in the pathogenesis of atheroslcerosis. While some genetic polymorphisms are related to phenotypical characteristics, others are not. Genetic polymorphisms of renin-angiotensin system, coagulation factors and atherogenic factors were most intensely studied. Insertion/deletion polymorphism of the angiotensin convertase, factor VII gene polymorphism, beta fibrinogen gene polymorphism, and apoprotein E gene polymorphism were associated with coronary artery disease and with ischemic cerebrovascular stroke. No significant association of genetic polymorphisms in the genes for factor V and angiotensin II receptor type 1 was found. Further studies on genetic polymorphisms in other candidate genes are expected to add new information in the understanding of atherosclerosis.
Summary		Ateroskleroza je model za multifaktorsko genetsko bolezen. Pri ugotavljanju vzročnih dejavnikov ateroskleroze so zanimivi različni kandidatni geni, ki so na različne načine vpleteni v etiopatogenezo ateroskleroze. Nekateri genetski polimorfizmi v kandidatnih genih so povezani z ugotovljenimi fenotipskimi razlikami, drugi pa ne. Največ raziskav je bilo narejenih s polimorfizmi renin-angiotenzinskega sistema, s polimorfizmi aterogenih dejavnikov in s polimorfizmi genov, ki so udeleženi v koagulacijski kaskadi. Asociacijske raziskave na različnih populacijah so ugotovile povezavo med insercija/delecija polimorfizmom angiotenzinske konvertaze, polimorfizmom gena za dejavnik VII, polimorfizmom gena za betafibrinogen in polimorfizmom gena za apoprotein E ter koronarno boleznijo in ishemičnim cerebrovaskularnim inzultom, medtem ko so le izjemoma ugotovili povezave med polimorfizmi angiotenzinogena, receptorja tip 1 angiotenzina II in dejavnika V ter koronarno boleznijo in ishemičnim cerebrovaskularnim inzultom. Od raziskav genetskih polimorfizmov v številnih drugih kandidatnih genih pričakujemo boljše razumevanje procesa aterogeneze.
Descriptors		ATHEROSCLEROSIS POLYMORPHISM (GENETICS) CORONARY DISEASE CEREBROVASCULAR DISORDERS