Author/Editor		Šabovič, Mišo
Title		Farmakološko zdravljenje ateroskleroze in njenih zapletov
Translated title		Pharmacological treatment of atherosclerosis and its complications
Type		članek
Source		Med Razgl
Vol. and No.		Letnik 37, št. Suppl 3
Publication year		1998
Volume		str. 125-30
Language		slo
Abstract		Atherosclerosis consists of three basic processes: occurrence of plaque, rupture of plaque and consequent thrombosis. All three processes can be influenced by pharmacological approaches: antiatherogenic and antithrombotic/thrombolytic treatment. Whereas the lattertreatment is already well established, the focus in last years has been put on antiatherogenic treatment, in particular on plaque stabilisation. In several clinical studies the efficacy of lipidlowering drugs and ACE inhibitors has been shown. In addition, antioxidants and estrogens have been shown to be antiatherogenic in certain subgroups of patients.
Summary		Proces ateroskleroze poteka skozi tri osnovna obdobja: nastanek in rast aterosklerotične lehe, ruptura lehe in tromboza na poškodovani lehi. S farmakološkim zdravljenjem poizkušamo ovirati vse tri procese; na prva dva vplivamo z antiaterogenim, na trombozo pa z antitrombotičnim in trombolitičnim zdravljenjem. Medtem ko sta antitrombotično in trombolitično zdravljenje že dobro uveljavljena v klinični praksi, je v zadnjih letih vedno več zanimanja za antiaterogeno zdravljenje, predvsem za farmakološko stabilizacijo leh. V kliničnih raziskavah so dokazali izrazito antiaterogeno učinkovitost zdravil, ki znižujejo koncentracijo holesterola. Antiaterogeni učinek imajo tudi ACE-inhibitorji, pri določenih podskupinah bolnikov pa tudi antioksidanti in estrogeni.
Descriptors		ATHEROSCLEROSIS ANTICHOLESTEREMIC AGENTS ANGIOTENSIN-CONVERTING ENZYME INHIBITORS ANTIOXIDANTS ESTROGENS FIBRINOLYTIC AGENTS