Author/Editor		Gubenšek, Franc; Križaj, Igor
Title		Ammodytoxins (Vipera ammodytes ammodytes)
Type		članek
Source		In: Rappuoli R, Montecucco C, editors. Guidebook to protein toxins and their use in cell biology. New York: Oxford university press,
Publication year		1997
Volume		str. 224-6
Language		eng
Abstract		Western sand viper (Vipera ammodytes ammodytes) venom contains considerable amounts of phospholipase A2-related toxins, among them ammodytoxins A, B, and C, which exhibit presynaptic neurotoxicity, and ammodytin L, which is myotoxic. Ammodytoxins act specifically at periphral nerve endings in motor end plates, and all these four bind to acceptors in bovine and Torpedo synaptosomal membranes. Their binding sites overlap to different extent with binding sites of some other phospholipase A2-based presynaptic neurotoxins and related non-neurotoxic proteins. The acceptor protein has partially characterized and is proposed to be a subunit of one of the subtypes of the K+ channels.
Descriptors		VIPER VENOMS SYNAPTIC MEMBRANES BINDING SITES PHOSPHOLIPASES A VIPERIDAE