Author/Editor		Derganc, M; Grosek, Š; Lazar, I; Moder, B; Gubina, M
Title		Spremembe povzročiteljev in diagnostika neonatalne sepse v enoti za intenzivno terapijo
Translated title		Changing causative microorganisms and diagnostics of neonatal sepsis in the paediatric intensive care unit
Type		članek
Source		Slov Pediatr
Vol. and No.		Letnik 5, št. Suppl 1
Publication year		1998
Volume		str. 152-6
Language		slo
Abstract		Between 1985 and 1996 the incidence of neonatal sepsis in the multidisciplinary paediatric ICU ranged from 9 to 25% (median 16,5%), 33% within 48 h of admission, 77% during hospitalization. Mortality ranged between 7.6 and 56% (median 22%). Gram negative organisms prevailed in blood cultures in mid -eighties, whereas in the ninties they decreased to 20% of isolated microorganisms. On the other hand, coagulase negative staphylococci (C-NS) increased from 8% to 61% of all isolates. Among diagnostic methods, surface cultures are being abandoned while improved blood culture methods and cerebrospinal fluid cultures remain the mainstay of diagnosis. Among laboratory tests, apart from sequential CRP determinations, newer test are being introduced, e.g. elastase alpha -1 proteinase inhibitor, interleukins -6 and -8 and procalcitonin.
Summary		Med letoma 1985 in 1996 je bila pogostnost sepse novorojenčka v Enoti za intenzivno terapijo (EIT) med 7,6 in 25% (povprečno 16,5%), od teh povprečno 33% ob sprejemu in 77% med hospitalizacijo. Smrtnost je nihala med 7,6 in 56% (mediana 22%). Med povzročitelji so v 80. letih prevladovale bakterije negativne po Gramu (do 60%), nato je postopno njihov odstotek podal do 20% v leu 1996. Odstotek koagulaza negativnih stafilokokov (K-NS) pa je narasel of 8 do 61% v letu 1996. Med diagnostičnimi metodami se opuščajo površinski brisi, najpomembnejše pa ostajajo izboljšane metode hemokultur in kultura likvorja. Med laboratorijskimi testi se, poleg spreminjanja dinamike CRP, uveljavljajo tudi novejši testi: elastaza alfa-1 proteinazni inhibitor (E alfa-1 PI), citokina -interlevkin-6 in -8 ter prokalcitonin.
Descriptors		INTENSIVE CARE UNITS, PEDIATRIC SEPSIS INFANT, NEWBORN