Author/Editor		Krbavčič, A; Pečar, S; Schara, M; Wiegrebe, W
Title		Anthranoid free radicals found in pseudomelanosis coli
Type		članek
Source		Pharmazie
Vol. and No.		Letnik 53, št. 5
Publication year		1998
Volume		str. 336-8
Language		eng
Abstract		Pseudomelanosis coli occurs after prolonged intake of anthranoids. After discontinuation of intake the pigmentation disappears apparently without noxious effects, including carcinogenicity and genotoxicity. We are presenting ESR spectra of pseudomelanosis coli specimen, compared to ESR spectra of pigmented skin scales taken from psoriatic patients treated topicaly with anthralin, and with ESR spectra of anthralin brown material formed in vitro. The ESR spectra show comparable g values within the accurac of measurements. The examined specimens reveal remarkable stability: the intensity of the ESR signal remained practically constant over the period of four years. The chemical and physicochemical properties ofthe brown pigments formed from anthranoids explain the observed bio-inertness of these materials including that of melanosis coli pigment derived from anthranoids.
Descriptors		ANTHRALIN CATHARTICS COLONIC DISEASES INTESTINAL MUCOSA ANTI-INFLAMMATORY AGENTS, TOPICAL COLON ELECTRON SPIN RESONANCE SPECTROSCOPY FREE RADICALS PSORIASIS SKIN