Author/Editor		Raivich, G; Jones, LL; Kreutzberg, GW
Title		Neuroglial activation in the injured brain: new insights from transgenic models
Type		članek
Source		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi Editore,
Publication year		1998
Volume		str. 19-28
Language		eng
Abstract		Damage to the central nervous system results in cellular changes not only in the injured neurons but also in the adjacent glial cells. This neuroglial activation is a common and routine hallmark in the injured brain and occurs in almost all forms of brain pathology. Recent work in mice that are genetically-deficient for different cytokines (M-CSF, IL-6, TNF-alpha, or TGF-beta1) has begun to shed light on the molecular signals that regulate this cellular response. Here, the availability of cytokine-deficient animals with reduced or abolished neuroglial activation provides a direct approach to determine the function of the different components of the cellular response, leading to repair and regeneration following neural trauma.
Descriptors		CENTRAL NERVOUS SYSTEM NERVE REGENERATION ASTROCYTES MICROGLIA CYTOKINES MICE MACROPHAGE COLONY-STIMULATING FACTOR TUMOR NECROSIS FACTOR INTERLEUKIN-6 TRANSFORMING GROWTH FACTOR BETA