Author/Editor		Nevšimalova, S; Mignot, E
Title		The role of genetic factors in the development of narcolepsy and hypersomnia in children
Type		članek
Source		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi Editore,
Publication year		1998
Volume		str. 63-8
Language		eng
Abstract		Hereditary factors play an important role in the development of some sleep disorders including narcolepsy and hyersomnia. Both conditions develop, as a rule, in adolescence and have,at this age, some clinical as well as polygraphical distinctions compared with fully expressed symptoms in adults. Genetic predisposition can facilitate correct diagnosis in the early stage of the disease. In this study, the empirical risk of narcolepsy-cataplexy developing in first degree relatives was found to be up to 100 times greater than in the general Czech population. HLA DR2+ and DQBI *0602+ were found in only 2/3 ofthe familial cases of narcolepsy-cataplexy. A negative HLA-DR2 haplotype does not consequently exclude a later development of the disease in children coming from multiple-case narcolepsy families. A convincing genetic predisposition was found in the polysymptomatic form of idiopathic hypersomnia. Sleep drunkennes isfrequently the first sign seen in affected children.
Descriptors		HYPERSOMNIA NARCOLEPSY HLA-DR2 ANTIGEN CHILD