Author/Editor		Civardi, C; Naldi, P; Cantello, R; Mutani, R
Title		Changes of cortico-spinal excitability in obstructive sleep apnea
Type		članek
Source		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi editore,
Publication year		1998
Volume		str. 125-9
Language		eng
Abstract		Motor cortical excitability is depressed during non-REM sleep in normal subjects. We have used single pulse transcranial magnetic stimulation in 5 patients with obstructive sleep apnoea syndrome (OSAS), to assess the relaxed threshold, silent period and the modification in amplitude of a test stimulus in wake, non-REM sleep and non-REM sleep during apnoea. Threshold was normal (52.6% +- 3.6), the lasting of the silent period was increased (252 +- 16 msec). During non-REM sleep the amplitude of the test motor evoked potential was reduced (52% of control; +- 7.2) if compared with an awake condition, we observed a further decreased in amplitude (14% of control; +- 6.5) when the same stimulus was given within apnoea. This transient modification of the cortical excitability may somehow relate to the intrinsic mechanisms of the OSAS pathophysiology.
Descriptors		SLEEP APNEA SYNDROMES SLEEP STAGES NEUROPHYSIOLOGY EVOKED POTENTIALS, MOTOR MAGNETICS