Author/Editor		Marinković, D; Totić, S; Babinski, T; Paunović, VR
Title		Pharmacological sleep modulation - effects of 5-HT2 antagonist (clozapine)
Type		članek
Source		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi editore,
Publication year		1998
Volume		str. 455-8
Language		eng
Abstract		Many studies suggest that serotonin (5-HT) plays a critical role in the production of sleep (especially NREM sleep), but the effects of different 5-HT acting agents are often difficult to interpret. The aim of this sleep study was to examine effects of 5-HT2 antagonist (clozapine) on sleep architecture restoration in patients with severe, chronic insomnia, suffering from alcoholic and organic hallucinosis. Sleep-staging is performed by Medilog system, using two drugs: flurazepam 60 mg and clozapine 50 mg and 75 mg, respectively. While administration of benzodiazepine hypnotic did not show any improvement in patients sleep profile, clozapine appliance 50 mg and 75 mg dosage, prolonged total sleep time, improved sleep efficiency, shortened sleep latency, prolonged REM latency and considerably promoted slow-wave sleep. The results of this study pointed out that 5-HT, antagonists may successfully recover deep stages of NREM sleep.
Descriptors		SLEEP CLOZAPINE INSOMNIA SLEEP STAGES