Author/Editor     Medaglini, S; Zucconi, M; Locatelli, T; Fornara, C; Weber, G; Chiumello, G; Comi, G
Title     Hypothalamic syndrome: a five years follow-up study
Type     članek
Source     In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi Editore,
Publication year     1998
Volume     str. 607-10
Language     eng
Abstract     The hypothalamic syndrome (HS) is characterized by obesity, hypothermia, hypersomnolence, central sleep apneas, severe bradycardia with endocrine and electrolyte dysfunctions. A treatment with clomipramine firstly described by Laron(1986), resulted in a clear improvement of central apneas, biochemical and clinical parameters. In our previous study, we described two cases of HS with severe central sleep apneas who showed a good response to the treatment with fluoxetine, a specific 5HT reputake inhibitor, suggesting also a role of serotonin in respiratory control and in some endocrine dysfunctions. The treatment was prolonged for about 2 years. The improvement of clinical and respiratory parameters persisted along the time nevertheless the fluoxetine withdrawal. We described the results of the five years follow.-up.
Descriptors     HYPOTHALAMIC DISEASES
CHILD
OBESITY
HYPOTHERMIA
HYPERSOMNIA
SLEEP APNEA SYNDROMES
BRADYCARDIA
ELECTROENCEPHALOGRAPHY
EVOKED POTENTIALS, AUDITORY
POLYSOMNOGRAPHY