Author/Editor		Leocani, L; Rossi, P; Martinelli, V; Filippi, M; Medaglini, S; Santuccio, G; Martinelli, F; Rocca, MA; Comi, G
Title		Longitudinal evaluation of multimodal evoked potentials in progressive multiple sclerosis: correlations with clinical and brain MRI findings
Type		članek
Source		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi Editore,
Publication year		1998
Volume		str. 653-6
Language		eng
Abstract		In a previous transversal study we found a significant correlation between Evoked Potentials (EPs) abnormalities and disability in patients with progressive Multiple Sclerosis (PMS). In the present study we performed a longitudinal evaluation in 32 PMS patients (13M, 19F; mean age 42.3+-9 years) with a mean disease duration of 11.7+-7.2 yrs at a mean baseline EDSS score of 5.3+-1.1. All patients underwent the following evaluations at baseline and after 2 years: EDSS, brain MRI, multimodal EPs (visual, auditory, upper and lower limb somatosensory and motor). Kurtyke's Functional Systems (FS) were utilized to quantify clinical symptoms and signs. EPs abnormalities were quantified according to a conventional 4 graded score (0=normal. 3=severe abnormalities). Cross-sectional analysis showed, for each sensory pathway, a significant correlation between clinical and EPs findings. However, longitudinal correlations were significant for somatosensory pathways only. The global EPs score was significantly correlated to EDSS both in cross-sectional and longitudinal analysis. No correlations were found between MRI and EDSS, nor between MRI and EPs, with the exception of the cross-sectional follow-up evaluations.
Descriptors		MULTIPLE SCLEROSIS EVOKED POTENTIALS MAGNETIC RESONANCE IMAGING BRAIN EVOKED POTENTIALS, VISUAL EVOKED POTENTIALS, AUDITORY EVOKED POTENTIALS, SOMATOSENSORY EVOKED POTENTIALS, MOTOR CROSS-SECTIONAL STUDIES