Author/Editor		Kountouris, D
Title		Intravenous immunoglobulin in the treatment of resistant in antibiotics fever immunocompromised multiple sclerosis patient
Type		članek
Source		In: Stalberg EV, de Weerd AW, Zidar J, editors. ECCN 98. 9th European congress of clinical neurophysiology; 1998 Jun 4-7; Ljubljana. Bologna: Monduzzi editore,
Publication year		1998
Volume		str. 701-3
Language		eng
Abstract		Septic and immunocompromised patients are appear with impaired phagocytic function of neutrophils and monocytes. Recent clinical studies suggest that Intravenous Immunoglobulin (IVIG), among its immunomodulatory effects, exerts an antimicrobial activity, improving the outcome of severely septic patients. On the other hand, prophylactic administration of IVIG reduces the number. of infectious episodes in patients submitted bone marrow transplantation. In addition, IVIG administration has shown antipyretic activity in an experimental model of fever in rabbits. This paper is referred in 12 immunocompromised Multiple Sclerosis (MS) patients (8 female and 4 male) who experienced a dramatic decline of fever and a clinical improvement, after IVIG administration. All these patients were been admitted to hospital because they presented a long history of fever refractory to antibiotics. The observations shows that the IVIG is a useful therapeutic tool for these specific occasions and should be administrated immediately.
Descriptors		MULTIPLE SCLEROSIS IMMUNOCOMPROMISED HOST SEPSIS ANTIBIOTICS BONE MARROW TRANSPLANTATION IMMUNOGLOBULINS, INTRAVENOUS