Author/Editor		Debeljak, Andrej; Mušič, Ema; Kumelj, Marko
Title		Bakterijska poslabšanja kronične obstruktivne pljučne bolezni (KOPB) in občutljivost za antibiotike
Translated title		Bacterial exacerbations of chronic obstructive pulmonary disease (COPD) and sensitivity for antibiotics
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 67, št. 5
Publication year		1998
Volume		str. 285-8
Language		slo
Abstract		Background. The aim of our study was to find out bacterial species responsable for acute bacterial exacerbations and their susceptibility to antibiotics in patients with COPD admitted to our hospital in the year 1995. Methods. Retrospectively we analysed sputum bacteriologic cultures and sensitivities in 1291 patients with severe exacerbations of COPD. Among them there were 142 males and 49 females, aged 70+-9. Patients were referred to hospital due to home management failure. Results. Two hundred forty-nine potential pathogens were recovered during 315 bacterial exacerbations. We confirmed Streptococcus pneumoniae in 78 (41%), Haemophilus influenzae and parainfluenzae in 53 (28%), Moraxella catarrhalis in 31 (16%), Pseudomonas aeruginosa in 43 (23%) and Staphylococcus aresus in 32 (17%) of patients. Clindamycin, cefotaxim, amoxicillin, amoxicillin/clavulanic acid, penicillin were in vitro active against Streptococcus pneumoniae in 73-60 cases (99%-81%). Ciprofloxacin, pefloxacin, cefuroxim, ampicillin/sulbactam, amoxicallin/clavulanic acid and azytromycin were efficient in vitro against Haemophilus species in 48-41 cases (100%-85%). Amoxicillin/clavulanic acid, ampicillin/sulbactam, cefotaxim, cefuroxim and roxitromycin were in vitro effective against Moraxella catarrhalis in all 28 case (10%). Azytromycin, ciprofloxacin and pefloxacin were active to the same bacteriain 27-25 cases (96%-89%). Pseudomonas aeruginosa was in vitro sensitive forceftazidime, imipenem, azlocillin, amikacin and ciprofloxacin in 36-25 cases (88%-61%). Efficiency for Staphylococcus aureus was in 30-17 cases (100%-57%) for vancomycian, netilmicin, ceftazidime, cefazolin, cefuroxime, and gentamycin.(Abstract truncated at 2000 characters.)
Summary		Izhodišča. Cilj študije je bil ugotoviti bakterijske vrste, ki so najverjetneje povzročile akutna poslabšanja in njihovo občutljivost na antibiotike pri bolnikih s KOPB, sprejetih v našo bolnišnico v letu 1995. Metode. Retrospektivno smo pregledali bakteriološke kulture sputumor in občutljivosti pri 191 bolnikih s hudimi poslabšanji KOPB. Bilo je 142 moških in 49 žensk, starih 70+-9 let. Bolniki so bili poslani v bolnišnico, ker zdravljnjenje doma ni bilo uspešno. Rezultati. Med 315 poslabšanji bolezni smo verjetno patogene mikroorganizme izolirali 249-krat. Ugotovili smo naslednje povzročitelje: Streptococcus pneumoniae pri 78 (41%), Haemophilus influenzae in parainfluenzae pri 53 (38%), Moraxellacatarrhalis pri (16%). Pseudomonas aeruginosa pri 43 (23%) in Staphylococcus aureus pri 32 (17%) bolnikih. Klindamicin, cefotaksim, amoksicilin,amoksicilin/klavulanska kislina, penicilin so bili invitro aktivni proti povzročitelju Streptococcus pneumoniae pri 73-60 sevih (99%-81%). Ciprofloksacin,pefloksacin, cefuroksim, ampicilin/sulbaktam, amoksicilin s klavulansko kislino, azitromicin so bili in vitro učinkoviti proti povzročiteljem Haemophylus influenzae pri 48-41 sevih (100%-85%). Amoksicilin/klavulanska kislina, ampicilin/sulbaktam, cefotaksim cefuroksim in roksitromicin so bili in vitro učinkoviti pri vseh 28 sevih povzročitelja Moraxella catarrhalis (100%). Azitromicin, ciprofloksacin so bili učinkoviti proti isti bakteriji pri 27-25 sevih (96%-89%). Od 36-25 sevov (88%-61%) povzročitelja Pseudomonas aerugionosa je bilo ni vitro obučutljivih za ceftazidim, imipenem, azlocilin, amikacin in ciprofloksacin, ter 30-17 sevov (100%-57%) povzročitelja Staphylococcus aureus je bilo občutljivih za vankomicin, netilmicin, ceftazidim, cefazoli, cefuroksim in gentamicin. (Izvleček prekinjen pri 2000 znakih.)
Descriptors		LUNG DISEASES, OBSTRUCTIVE BACTERIAL INFECTIONS MICROBIAL SENSITIVITY TESTS DRUG RESISTANCE, MICROBIAL SPUTUM ANTIBIOTICS