Author/Editor		Sket, Dušan
Title		Alzheimerjeva bolezen: molekularne hipoteze in poskusi farmakoterapije
Translated title		Alzheimer's disease: molecular hypotheses and pharmacotherapeutic prospects
Type		članek
Source		Farm Vestn
Vol. and No.		Letnik 49, št. 2
Publication year		1998
Volume		str. 143-51
Language		slo
Abstract		Alzheimer's disease represents the most common form of late onset dementia, that develops over the age of 65 years. The early onset (presenile) forms of Alzheimer's disease are less common. The disease is characterized by progressive clinical course; the definite diagnosis is based on the histological demonstration of neurofibrillary tangles and senile plaques in the brain after autopsy. The article presents a short review of the leading molecular hypothese of Alzheimer's disease and current pharmacotherapeutic prospects.
Summary		Alzheimerjeva bolezen predstavlja poglavitno obliko demence, ki se pojavlja pri ljudeh v starosti nad 65 let. Redkejše so oblike presenilne demence, ki se pojavljajo pred 65. letom. Poleg značilnega progresivnega kliničnega poteka je za potrditev diagnoze potreben histološki pregled požganov po smrti, ki razkrije veliko koncentracijo senilnih leh in nevrofibrialnih pentelj. V članku so na kratko predstavljene vodilne molekularne hipoteze Alzheimerjeve bolezni in pogledi na možnosti farmakoterapije.
Descriptors		ALZHEIMER'S DISEASE DEMENTIA NEUROFIBRILLARY TANGLES AMYLOID BETA-PROTEIN AMYLOID BETA-PROTEIN PRECURSOR APOLIPOPROTEINS E CHOLINESTERASE INHIBITORS TAU PROTEINS