Author/Editor		Šiška, Arijan; Babič, Ankica; Pavešić, Nikola
Title		Studies of responsiveness in the R-EGFR and Rcerb-B2 oncogenes spaces: a customized application for thyroid lesions
Type		članek
Source		In: Pappas C, Maglaveras N, Scherrer J-R, editors. Medical informatics Europe '97. Amsterdam: IOS Press,
Publication year		1997
Volume		str. 634-7
Language		eng
Abstract		Among verity of diagnostic approaches suitable for clinical analysys of thyrond lesions, the two oncogenes (R-EGFR and Rcerb-B2) are believed to be of discriminative power. In a retrospectively collected patient material we have difined different lesion types (normal tissue, bengn and pregnant tumors). Those were taken as class definitions in analysis performed to assign discriminanting perfomance. Standard multivariate statistics has not performed satisfactory partly due to the data distribution to presence of the noise. Therefor we have developed a method for purpose the classification which was based on principle of minimising generalised classification error. Results of the separation between carcinoma normal tissue reached accuracy 70%, other classification attempts endea up in poor results. In general, musclassifications could be explained with the data quality (norse) and, when it canne to benign lesions with rexposiveness of the oncogenes to tumours tissues.
Descriptors		THYROID NEOPLASMS PROTO-ONCOGENES MULTIVARIATE ANALYSIS