Author/Editor		Rode, Mirela
Title		Vloga sline pri preprečevanju intraoralnih komplikacij po obsevanju
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1998
Volume		str. 72
Language		slo
Abstract		Aim. The aim of the present study was to explore and evaluate the effect of parasympathomimetic pilocarpine and anticholinergic biperiden on the secretion and composition of saliva in patients with malignant tumors of the head and neck, and to define their role in the prevention of adverse sequels of radiotherapy. The study is based on the hypothesis that in patients irradiated for head and neck cancer, the glandular parenchyma can be successfully protected against radiation-related damage by inhibition of the parasympathetic system. It is believed that non-active glandular parenchyma should be less susceptible to irradiation than those stimulated to saliva secretion It was also presumed that after completion of radiotherapy, parasympathetic stimulation could result in increased saliva production, which would contribute to a decrease in postradiation xerostomy and the related adverse effects on the hard and soft tissues of the oral cavity. Materials and methods. Our study was caried out in a series of 69 patients who were irradiated for head and neck cancer during which the salivary glands were included in the irradiation field. The patients were randomized into three groups (A, B and C). Group A consited of patients receiving pilocarpine, Group B of those who were receiving biperiden during radiotherapy, and pilocarpine for six weeks after its completion, while Group C comprised patients not receiving any xerostomy prevention therapy during or after radiotherapy. The daily fraction of radion doe was 2 Gy in all patients. Their distribution by stage, site and mode of irradiation did not vary significantly from one group to another.(Abstract truncated at 2000 characters.)
Descriptors		HEAD AND NECK NEOPLASMS RADIOTHERAPY SALIVARY GLANDS SALIVA SALIVATION PILOCARPINE BIPERIDEN XEROSTOMIA CALCIUM BICARBONATES HYDROGEN-ION CONCENTRATION