Author/Editor		Kragelj, Rudi; Šemrov, Dejan; Karba, Rihard; Čemažar, Maja; Serša, Gregor; Miklavčič, Damijan
Title		Korelacija med učinkovitostjo elektrokemoterapije in električnim poljem v poskusnem tumorskem modelu
Translated title		Correlation between effectiveness of electrochemotherapy and electric field in experimental tumor model
Type		članek
Source		In: Zajc B, editor. Zbornik 7. elektrotehniške in računalniške konference ERK'98. Zvezek B. Računalništvo in informatika, umetna inteligenca, robotika, razpoznavanje vzorcev, biomedicinska tehnika, močnostna elektrotehnika, didaktika, študentski članki; 1998 sep 24-26; Portorož. Ljubljana: Slovenska sekcija IEEE,
Publication year		1998
Volume		str. 395-8
Language		slo
Abstract		Electrochemotherapy is an efficient way to treat solid tumors. it enhances the effectiveness of chemotherapeutic agent by administring the drug in combination with short intense electric pulses. Electric pulses permeabilize plazma membrane and allow the cytotoxic drug, such as bleomycin or cisplatin, to enter the cell. Different electrode geometry and elctrode configuration, previously examined in experimental studies, were modelled using mathemathical model and three dimensional finite element model. In our study we 1) designed mathematical model of tumor growth after various treatments, 2) determined raction of surviving cells after each therapy, 3) determined fraction of nonporated cells, and 4) compored the results of mathematical models with the calculated values of electric field obtained with numerical model. The results of the study clearly demonstrate that both models can be useful in additional search of the electrochemotherapy improved effectiveness. Our study also shows that minimal fraction of non-porated cells can be obtained by changing the electrode orientation. The surviving fraction of cells that were not killed in spite of treatment is still high enough for the tumor regrowth. Larger drug dose and apropriate immunotherapy can be useful methods to eliminate this fraction.
Descriptors		ELECTRIC STIMULATION THERAPY SARCOMA, EXPERIMENTAL BLEOMYCIN CELL SURVIVAL MICE NUMERICAL ANALYSIS, COMPUTER-ASSISTED MODELS, THEORETICAL