Author/Editor		Šajina-Stritar, Barbara
Title		Učinkovitost acetilsalicilne kisline in N-3 nenasičenih maščobnih kislin v preprečevanju zapletov hipertenzivnih bolezni v nosečnosti
Translated title		The effect of acetylsalicylic acid and N-3 fatty acids in prevention of complications of hypertension diseases in pregnancy
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 67, št. 9
Publication year		1998
Volume		str. 489-93
Language		slo
Abstract		Background. Gestational hypertension (GH) is diseases which occurs only in pegnancy. It is associated with high maternal and perinatal morbidity and mortality. The increased production of tromboxane A2 (TXA) and decreased production of tromboxane A2 (TXA2) and decreased production of prostacycline (PGI2) play an important role in aetiology of GH. Acetylsalicylic acid (ASA) and N-3 fatty acids proved to be effective in the prevention of GH. Methods. Forty-eight patients who were judged to be at particulary high risk for GH on the basis of their obstetric history were randomly allocated to three groups. Twelve patients in group A were given daily 100 mg ASA (1 tablet of Aspirin 0.1) from 16th week of pregnancy until delivery. Eleven patients in groupsT were given daily 300 mg of fish oil (6 capsuls of Treinyl) from 16th week of pregnancy until delivery. Twenty-five patients in group C received no therapy. All patients underwent the same monitoring procedures. The differences among groups were detected by the statistical procedures of hi-square and Students t-test. Results. Gestational hypertension occured in 50% of patients in group A, 60% ingroup T and 80% in group C. The highest blood pressure was found in patients in group C. The diastolic blood presure was statistically significantly higher in group C compared to group T (p < 0.05). Half of the patients in group C needed additional antihypertensive therapy during pregnancy. The difference in additional antihypertensive therapy between groups T and C was statistically significant (p < 0.05). The number of hospital days per patient was the lowest in group T. The difference in hospital days per patient between groups A and T was statistically significant (p < 0.01).(Abstract truncated at 200 characters)
Summary		Izhodišča. Gestacijska hipertenzija (GH) je bolezen, ki se pojavi samo v nosečnosti oziroma ob prisotnosti horionskega tkiva. Povezana je z visoko maternalno in perinatalno zbolevnostjo in umrljivostjo. Pomembno vlogo pri nastanku GH ima porušeno razmerje med prostaglandinoma (PG) prostaciklinom (PGI2) in tromboksanom A2 (TXA2). Dosedanje študije so pokazale, da sta v preprečevanju GH najuspešnejša acetilsalicilna kislina (AKS) in N-3 nenasičene maščobne kisline (n.m.k.). Metode. V študijo smo vključili 48 nosečnic, ki so imele v prvi nosečnosti GH, preeklampsijo, eklampsijo, nacepljeno hipertenzijo, prezgodnjo ločitev pravilno ležeče posteljice, znotrajmaternični zastoj v rasti ploda ali smrt ploda v maternici. Po naključnem izboru smo jih razdelil v tri skupine. Dvanajst nosečnic v skupni A je od 16. tedna nosečnosti do poroda jemalo 100 mg ASK (1 tableto aspirina 0,1) na dan. Enajst nosečnic v skupini T je od 16. tedna nosečnosti do poroda jemalo 3000 mg ribjega olja (6 kapsul Trinyla) na dan. Petindvajset nosečnic v kontrolni skupini C ni dobilo nobenega zdravila. Skupine smo med seboj primerjali glede na potek in izid nosečnosti in poroda. Pri statistični obdelavi rezultatov smo uprabili Studentov t-test in hi-kvadrat. Za statistično značilno smo upoštevali p <- 0,05. Rezultati. V skupini A je zbolelo 50%, v skupini T 60% in v skupini C 80% nosečnic. Nosečnice v skupini C so imele v času nosečnosti najvišje vrednosti krvnega tlaka. Razlika v višini najvišjega diastoličnega krvnega tlaka med skupino T in C je statitistično značilno (p < 0,05). V skupini C je polovica porodov morali inducirati zaradi ogroženosti matere in/ali ploda; med skupino A in C je statistično značilna razlika (p < 0,03).(Izvleček prekinjen pri 2000 znakih)
Descriptors		GESTOSIS, EPH ASPIRIN FATTY ACIDS, OMEGA-3 PREGNANCY PROSTAGLANDINS EPOPROSTENOL THROMBOXANE A2 HYPERTENSION