Author/Editor		Turel, Iztok; Golič, Ljubo; Bukovec, Peter; Gubina, Marija
Title		Antibacterial tests of Bismuth(III)-quinolone (ciprofloxacin, cf) compounds against Helicobacter pylori and some other bacteria. Crystal structure of (cfH2)2(Bi2Cl10).4H2O
Type		članek
Source		J Inorg Biochem
Vol. and No.		Letnik 71
Publication year		1998
Volume		str. 53-60
Language		eng
Abstract		The antibacterial tests of two bismuth(III)-ciprofloxacin (cf) compounds against Helicobacter pylori (H.pylori) and some other bacteria were performed. The results have shown that the activity of both compounds is comparable to that of ciprofloxacin hydrochloride. The crystal structure of (cfH2)2(Bi2Cl10).4H2O(cfH2=duobly protonated molecule of cf) is presented and discussed. The compound was isolated from acidic medium where quinolone is protonated and thus no bonding between quinolone and bismuth was observed. The bismuth(III) ions are coordinated by chloride ions forming dinuclear (Bi2Cl10)4- anions. The charge of this ion is compensated with protonated quinolone molecules (ionic interactions).
Descriptors		HELICOBACTER PYLORI BISMUTH ANTI-INFECTIVE AGENTS, QUINOLONE CIPROFLOXACIN CRYSTALLINS MICROBIAL SENSITIVITY TESTS DRUG COMPOUNDING STREPTOCOCCUS ENTEROCOCCUS