Author/Editor		Cosyns, Jean-Pierre; Malaise, Jacques; Hanique, Genevive; Mourad, Michel; Baldi, Alessandra; Goebbels, Rose-Marie; Squifflet, Jean-Paul
Title		Lesions in donor kidneys: nature, incidence and influence on graft function
Type		članek
Source		In: Bren AF, Ferluga D, Olsen S, et al, editors. Proceedings of the International conference on transplantation with emphasis on kidney; 1998 Oct 8-9; Ljubljana, Slovenia. Ljubljana: Medical faculty, Institute of pathology,
Publication year		1998
Volume		str. 38-40
Language		eng
Abstract		The aim of this study was to assess the influence of kidney donor-transmitted pathology on graft function. Light and immunofluorescence microscopy findings from a surgical biopsy taken prior to transplantation from 114 cadaveric kidney donors were analyzed. moderate to severe mesangial IgA deposits were considered consistent with IgA nephropathy. Pathological abnormalities were correlated together with donor age, number of mismatches and type of immunosuppression by multivariate statistical analysis with the serum creatinine values from patients who experienced no acute rejection at one year. Serum creatinine values (n = 52) were not correlated with either non-specific light microscopy lesions or immunofluorescent deposits found in the majority of kidney donors or with changes consistent with IgA nephropathy observed in 9% of the cases. There was, however, a correlation with donor age which was also correlated with the extent of chronic lesions (p < 0.001).
Descriptors		KIDNEY TRANSPLANTATION TISSUE DONORS KIDNEY GLOMERULONEPHRITIS, IGA BIOPSY CREATININE MICROSCOPY, FLUORESCENCE GRAFT VS HOST REACTION