Author/Editor		Vizjak, Alenka; Jurčić, Vesna; Ferluga, Dušan
Title		Immune reactant deposits in renal transplant biopsies
Type		članek
Source		In: Bren AF, Ferluga D, Olsen S, et al, editors. Proceedings of the International conference on transplantation with emphasis on kidney; 1998 Oct 8-9; Ljubljana, Slovenia. Ljubljana: Medical faculty, Institute of pathology,
Publication year		1998
Volume		str. 42-6
Language		eng
Abstract		The role of humoral immunity in rejection is still not clearly delineated. This study analysed 101 renal transplant biopsies from 69 patients (43 men, 26 women, age range 9-71 years) and 31 control normal kidneys by light and immunofluorescence microscopy techniques. Glomerular immune deposits were found in 88% of transplant biopsies, with suggested immune allografts. Extraglomerular vascular immune deposits were observed in 97% of renal transplant biopsies and 55% of normal kidney. igM and C3 with fine granular pattern were associated with acute vascular rejection, while homogeneous lumpy deposits occured mostly in chronic transplant nephropathy as well as non-rejection vascular lesions. Granular and rarely linear deposition of IgG, IgM and/or C3 along the tubular membrane and in interstitial capillaries were observed in renal transplant biopsies not associated with any histomorphologic group. In conclusion, immune reactant deposition is a frequent finding in kidney transplant biopsies. The observation of characteristic vascular immune deposits in acute vascular rejection is compatible with humoral mechanism of rejection.
Descriptors		KIDNEY TRANSPLANTATION TISSUE DONORS KIDNEY GRAFT REJECTION BIOPSY GRAFT OCCLUSION, VASCULAR FLUORESCENT ANTIBODY TECHNIQUE ANTIGEN-ANTIBODY COMPLEX