Author/Editor		Pokorna, Eva; Vitko, Štefan; Chamidova, Maria; Schueck, Ota
Title		Serious morphological changes in the donor kidney, onset of function and graft survival
Type		članek
Source		In: Bren AF, Ferluga D, Olsen S, et al, editors. Proceedings of the International conference on transplantation with emphasis on kidney; 1998 Oct 8-9; Ljubljana, Slovenia. Ljubljana: Medical faculty, Institute of pathology,
Publication year		1998
Volume		str. 91-2
Language		eng
Abstract		180 biopsies were evaluated histologically from 300 cadaveric kidney donors. We have observed sclerotic glomeruli, vascular insudates and interstitial fibrosis. The histological findings were divided into two groups: a control group C without/or with minimal histological changes, and a marginal group M with a higher incidence of sclerotic glomeruli (P<.0001), vascular insudates (P<.0001) and interstitial fibrosis (P<.0001). Following clinical data of donors were reviewed: age, sex, cause of brain death, arterial hypertension. Group M donors were older (P<.0001) and with a higher incidence of hypertension (P<.0001) than in the group C. The onset of graft-function was evaluated as immediate or delayed. The level of function was rated as the lowest value of S-creatinine after transplantation and at 6, 12, 18, 24, 36 months post transplant periods. The early graft-function did not differ when the two groups were compared. Renal graft recipients showed higher levels of S-creatinine with the histological changes corresponding to vascular insudates. The on eyear graft survival rates also did not differ between groups. The two-years and three-years graft survival rates were lower in the group M (P<.05) than in the group C.
Descriptors		KIDNEY TRANSPLANTATION TISSUE DONORS KIDNEY GRAFT SURVIVAL BIOPSY CADAVER