Author/Editor		Ferluga, Dušan; Kovač, Simon; Vranič, Andrej; Jurčić, Vesna
Title		Histopathology of renal allograft vasculature segments in kidney allograft rejection
Type		članek
Source		In: Bren AF, Ferluga D, Olsen S, et al, editors. Proceedings of the International conference on transplantation with emphasis on kidney; 1998 Oct 8-9; Ljubljana, Slovenia. Ljubljana: Medical faculty, Institute of pathology,
Publication year		1998
Volume		str. 107-11
Language		eng
Abstract		The aim of our study was systematically to evaluate and to compare histomorphological changes in different segments of the arterial bed in acute and chronic kindey allograft rejection. The study included 29 surgically removed kidney allografts, 8 with acute and 21 with chronic rejection. 13 kidneys removed at autopsies from an age-matched group of patients without clinically apparent kidney disease and without hypertension served as controls. Standard methodology for semiquantitative light microscopical evaluation of kidney specimens was applied. Significant differences in histomorphological changes in different vascular segments, although mianly quantitative, were clearly demonstrated. Intrarenal interlobar, acruate and large interlobular arteries were found to be the most intensively involved by inflammatory mononuclear cell infiltrative and proliferative rejection response. Large extrarenal arteries, although usually less severely affected, frequently show rejection related changes, including thrombo-necrotic lesions. Arterioles and small interlobular artieries appear to be significantly less frequently and less severely affected by inflammatory cell infiltration and proliferation than the other vascular segments. However, these vessels frequently show insudative-sclerosing changes. The involvement of arterioles of the medullary vasa recta and vasa vasorum of the large extrarenal and intrarenal vessels in the kidney allograft rejection have been the subject of research for the first time.
Descriptors		KIDNEY TRANSPLANTATION GRAFT REJECTION KIDNEY AUTOPSY GRAFT OCCLUSION, VASCULAR