Author/Editor		Jurčić, Vesna
Title		Adhesion molecules in kidney allograft rejection
Type		članek
Source		In: Bren AF, Ferluga D, Olsen S, et al, editors. Proceedings of the International conference on transplantation with emphasis on kidney; 1998 Oct 8-9; Ljubljana, Slovenia. Ljubljana: Medical faculty, Institute of pathology,
Publication year		1998
Volume		str. 47-9
Language		eng
Abstract		The author investigated the expression of cellular adhesion molecules (CAMs) ICAM-1, VCAM-1, Pecam and E-selection as well as HLA-DR and IL2-R in different structures of nephrectomy specimens of kidney allografts and in normal kidneys. In the normal kidneys, IL-2R and R-selection were absent. In contrast, ICAM-1 and PECAM were constituvely expressed by all andothelial cells, incliding the vasa recta of the medulla and large kidney vessels. Focal VCAM-1 positivity eas normally present only in capillaries and venules, the vessels important for leukocyte transmigration to the intersitium. These vessels were also diffusely positive for HLA-DR, and thus have a potential to present antigens, and may br a target of allospecific antibodies, as a part of humoral rejection mechanisms. Our study confirmed that in rejection, ICAM-1, VCAM-1 and HLA-DR were overexpressed on the tubuli and endothelium, which is probably important in mononuclear cell infiltration of the allograft, as a part of cellular rejection mechanisms. ICAM-1, VCAM-1 and HLA-DR were found to be upregulated in various vascular segments, including large intranenal vessels and vasa recta. The staining intensity was associated with the intensity of cell infiltration, probably as a consenquence of cytokines produced by activated mononuclear cells. However, the positivity of activation marker IL2-R, similar to E-selectin, was focal and may also be absent, perhaps because of weak or transient expression. Our results do not explain the segmental differences in the histopathology of kidney vessels, such as more prominent cell infiltration and less intensive insudative changes of arteries compared to arterioles. Furthermore, it was not possible to demonstrate tentative differences in expression of CAMs between acute and chronic rejection, since all our cases with chronic rejection contained also elements of acute relapse.
Descriptors		KIDNEY TRANSPLANTATION GRAFT REJECTION CELL ADHESION MOLECULES KIDNEY TRANSPLANTATION, HOMOLOGOUS INTERCELLULAR ADHESION MOLECULE-1 VASCULAR CELL ADHESION MOLECULE-1 HLA-DR ANTIGENS INTERLEUKIN-2 E-SELECTIN ANTIGENS, CD31