| Author/Editor | Bunc, Gorazd | |
| Title | Vpliv izključitve delovanja simpatičnega živčevja na spazem možganskih arterij po subarahnoidni krvavitvi pri kuncih | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1998 | |
| Volume | str. 66 | |
| Language | slo | |
| Abstract | Arterial cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAK) due to ruptured intracranial aneurysm is a huge and not yet solved problem in the field of neurosurgery. Regardless of even the most successful operative clipping of ruptured aneurysm, the disaster of clinically manifest CVS after three to fifteen days post SAK could compromite the postoperative result and couse delayed ishemic neurologic deficit of different intensity in about 30% of all cases of SAK. Recent investigations point to the numerous different mechanisms of patogenesis of CVS and show different components of blood mixed with CSF after SAK as a possible cause for CVS but neither of them is able to give a sufficiently competent answer to all problems about CVS and enable an efficient treatment at the same time. Hypothesis and objectives. The author and co-workers explored the hypothesis that the exclusion of the influence of the sympathetic nerous system (SNS) on cerebral arteries eliminated CVS after the experimental SAK in rabbits. To imitate the human conditions as close as possible they: - excluded the influence of SNS of cerebral arteries of rabbits after the experimental SAK since the first menagment of SAK inhumans could be started only when SAK is already diagnosed. - studied the exclusion of the influence of SNS in rabbits on eight day after SAK which is also the day of the most intense CVS in humans. - chose the single hemorrhage model of the experimental SAK. Methods and investigated animals. They excluded the influence of the SNS medicamentously by alpha blocking agent phenoxybenzamine and operatively by bilateral upper cervical sympathectomy. The effect of sympthetical exclusionon vessels was assessed hystologically by H. E. technique on the eight post SAK day by means of intracardial perfusion technique.(Abstract truncated at 2000 characters) | |
| Descriptors | SYMPATHETIC NERVOUS SYSTEM PHENOXYBENZAMINE SUBARACHNOID HEMORRHAGE CEREBRAL ARTERIES CONSTRICTION, PATHOLOGIC RABBITS |