Author/Editor     Kraut, Aleksandra
Title     Preiskava očesne prekatne vodke v razločevanju intraokularnih vnetij
Type     monografija
Place     Ljubljana
Publisher     Medicinska fakulteta
Publication year     1998
Volume     str. 41
Language     slo
Abstract     Background. Intraocular inflammation is a potentially blinding disorder that is initiated by a diverse group disease. The etiology in most cases is unknown, it can be infection but immunologic mechanisms are thought to play an important role in pathogenesis. The purpose of the study to determine and to establish a reatively noninvasive test of paracentesis to the etiologic diagnosis of the disease. Methods. During 1990 and the end 1995 we evaluated aqueous humor of t8 patients with various types of severe or indistinct intraocular inflammation. In 63 patients paired serum and intraocular fluid antibody levels were determed and the ratio of specific antibodies in serum and aqueous humor was calculated (Goldmann-Witmer quotient). Total Immunoglobulin IgG levels were determed in aqueous humor and serum in 43 patients with radio-immuno-diffusive method. In 12 patients cytological studies of aqueous humor were done. Results. The etiologic diagnosis of intraocular inflammation were confirmed inthree patients by higher level of antibodies in the aqueous humor comparing to the serum, and in eleven patients by calculated Goldmann-Witmer coefficients. Cytological analysis of aqueous humor gave us ideas for further investigations and in two patients etiologic diagnoses of fungal endophthalmitis by culture were confirmed. Mean value of total IgG concentration in 43 uveitic patients in the aqueous was 0,55 g/L (range 0,07 to 3,02). Concentrations of total IgG in the aqueous humor were increaseing with duration of the inflammation. Mean value in the control group was 0,11 g/L (range 0,08 to 0,16). Conclusions. Analysis of aqueous humor is safe and valuable tool in the diagnostic process of severe intracular inflammation or in cases with an ambiguous clinical presentation with presumed infectious ethiology.
Descriptors     AQUEOUS HUMOR
IGG
EYE INFECTIONS
ENDOPHTHALMITIS
UVEITIS
IGM
TOXOPLASMOSIS, OCULAR
TOXOCARA CANIS
HERPES SIMPLEX
HERPESVIRIDAE
CYTOMEGALOVIRUS
BORRELIA BURGDORFERI