Author/Editor		Kozak, Matija
Title		Ponovna zožitev periferne arterije po nekirurškem rekanalizacijskem posegu - ocena vloge fibrinolitičnega sistema
Type		monografija
Place		Ljubljana
Publisher		Medicinska fakulteta
Publication year		1998
Volume		str. 91
Language		slo
Abstract		Background: Percutaneous transluminal angioplasty (PTA) with or without concomitant thrombolysis has been widely used to treat insufficiency of the lower extremity arteries due to atherosclerosis. Restenosis after successful PTA and/or thrombolysis still remains an unsolved problem. Restenosis is a complex process that is not yet completely understood. The most important mechanisms involved in the development of restenosis include fibrointimal proliferation, synthesis of extracellular matrix and thrombosis. These processes are interrelated, but the regulating mechanisms are still unknown. The aim: The objective of our study was to identify some risk factors for post-PTA and postthrombolysis restenosis, with emphasis being placed on the role of fibrinolytic svstem, local hemodynamic factors, risk factors for atherosclerosis and lipoprotein(a). Patients and methods. After obtaining their informed consent, we studied 166 patients who had been successfully treated by PTA and/or thrombolysis for atherosclerotic lesions of the lower extremity arterv. There were 35 women and 131 men, aged 36 to 86 years (x=60). They had follow-up examinations one week and 3, 6 and 12 months after the procedure or later, until the detection of restenosis. The patency of the arterv was assessed noninvasively by ultrasound measurements of perfusion pressures and by calculating the ankle-brachial index. An index decreased by at least 15 per cent compared to post-recanalisation values, was considered to indicate restenosis. Three months after the procedure the following parameters were measured: t-PA antigen, t-PA activity and t-PA activity after venous occlusion, PAI antigen and activity, fibrinogen, plasminogen, euglobulin clot lysis time, alpha 2-antiplasmin. C reactive protein and lipoprotein (a). (Abstract truncated at 2000 characters)
Descriptors		ANGIOPLASTY, BALLOON THROMBOLYTIC THERAPY ARTERIAL OCCLUSIVE DISEASES ILIAC ARTERY FEMORAL ARTERY RISK FACTORS POPLITEAL ARTERY INTERMITTENT CLAUDICATION CHOLESTEROL TRIGLYCERIDES LIPOPROTEIN(A) C-REACTIVE PROTEIN ALTEPLASE PLASMINOGEN INACTIVATORS PLASMINOGEN ACTIVATOR INHIBITOR 1 FIBRINOGEN PLASMINOGEN ANTIPLASMIN