| Author/Editor | Volavšek, Metka | |
| Title | Tumorska neoangiogeneza pri incidentnem karcinomu prostate | |
| Type | monografija | |
| Place | Ljubljana | |
| Publisher | Medicinska fakulteta | |
| Publication year | 1998 | |
| Volume | str. 58 | |
| Language | slo | |
| Abstract | Incidental carcinoma of the prostate (ICP) is diagnosed in prostatic biopsies without previous knowledge of malignant disease. Its good prognosis is related to low stage at diagnosis. Only few cases are progressive and demand agressive treatment. C linical and patomorphologic studies of malignant diseases in different organs have proved the predictive value of neoangiogenesis determination in tumor progression and metastatic spread. The aim of our retrospective study was to disclose the significance and possible prognostic value of neoangiogenesis in ICP diagnosed in biopsy specimens after transurethral resection (TURP) at the Institute of Pathology, Medical Faculty in Ljubljana in years 1985-89. To determine how microvessels correlate with the degree of tumor differentiation determined histopathologically and with Gleason score, stage of disease, serum leves of prostatic specific antigen (PSA) and acid phosphatase (AF), and the time of survival in at least 6 years after diagnosis, we counted microvessels within the initial carcinoma in 68 patients. Microvessels were highlighted by immunostaining endothelial cells for factor VIII-related antigen. Without previous knowledge of clinical data, microvessels were counted in a x200 microscope field (0,8012 mm2) in the most active areas of neovascularisation. In the second part of the study we correlated neoangiogenesis and the degree of tumor differentiation between primary tumors and rebiopsies in 10 patients. Degree of tumor differentiation was also correlated with the time the disease progression occured. The higher maximal microvessel counts were associated with lower degree of tumor differentiation (p = 0,005), Gleason score (p = 0,001), stage of disease in primary tumors (0,003), and survival of the patients (0,05). No association between microvessel counts and stage of disease after progression, serum levels of PSA and AP was found. (Abstract truncated at 2000 characters) | |
| Descriptors | NEOVASCULARIZATION, PATHOLOGIC PROSTATIC NEOPLASMS BIOPSY PROSTATECTOMY IMMUNOHISTOCHEMISTRY PROSTATE-SPECIFIC ANTIGEN ACID PHOSPHATASE SURVIVAL ANALYSIS NEOPLASM STAGING FACTOR VIII |