Author/Editor		Korošec, L
Title		The pharmacokinetic properties of current systemic antifungal agents
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 7, št. 3-4
Publication year		1998
Volume		str. 145-51
Language		eng
Abstract		Human fungal infections have increased dramatically and are difficult to treat. The spread of HIV/AIDS infection, the use of immunosuppressive drugs and broad-spectrum antibiotics have contributed to the spread of fungal infections. Spontaneous remissions are rare, and recurrence after treatment is common. The pharmacotherapy of the fungal diseases has been revolutionized by the introduction of the relatively non-toxic oral azoles. The systemic treatment with the new antifungal agents - fluconazole, itraconazole, and terbinafine - and the knowledge of their pharmacological and pharmacokinetic properties make possible the pulse therapy in the treatment of the fungal infestions. This will be of great benefit for patients from pharmacological as well as pharmacoeconomic aspects.
Descriptors		DERMATOMYCOSES ANTIFUNGAL AGENTS ONYCHOMYCOSIS ADMINISTRATION, ORAL KETOCONAZOLE FLUCONAZOLE ITRACONAZOLE ALLYLAMINE