Author/Editor		Jezeršek, Barbara; Novaković, Srdjan
Title		p53 - the paradigm of tumor-suppressor genes?
Translated title		Tumorski supresor gen p53
Type		članek
Source		Radiol Oncol
Vol. and No.		Letnik 32, št. 4
Publication year		1998
Volume		str. 373-83
Language		eng
Abstract		p53 is a tumor-suppressor gene the alterations of which are among the most frequent genetic changes detected in human neoplasms. Its product - p53 protein is a component of several biochemical pathways that are central to carcinogenesis: DNA transcription, genomic stability, DNA repair, cell cycle control, and apoptosis. The analysis of the spectrum of p53 mutations and insight into the p53 mediated biochemical pathways of programmed cell death and cell cycle arrest, provide clues to understanding of molecular pathogenesis of cancer of mechanisms related to p53 mediated tumor suppression. The purpose of the resent article is to summarise the most important facts concerning p53 since understanding of the above listed processes might provide the potential molecular targets for the development of a rational cancer treatment.
Summary		Spremembe tumor supresorksega gena p53 so najpogostejše genetske spremembe, ki so jih doslej odkrili pri bolnikih z malignimi boleznimi. Proizvod omenjenega gena - p53 protein je namreč pomemben element različnih biokemičnih poti, ki so ključne v procesu karcinogeneze: vključno s procesom prepisovanja DNA, ohranjanja stabilnosti genoma, popravljanja poškodb DNA, ter kontrolo celičnega ciklusa. Analiza mutacij p53 gena in spoznavanje biokemičnih poti programirane celične smrti ter zaustavitve celičnega ciklusa, ki ju sproži p53 protein, sta prispevala k razumevanju patogeneze raka na molekularnem nivoju, kot tudi mehanizmov, preko katerih p53 deluje kot "zaviralec" tumorjev. Namen tega preglednega članka je strniti doseadanja dognanja o p53, saj naj bi razumevanje navedenih procesov v bodoče olajšalo iskanje novih racionalnih pristopov k zdravljenju malignih bolezni na molekularnem nivoju.
Descriptors		GENES, SUPPRESSOR, TUMOR GENES, P53 PROTEIN P53 TRANSCRIPTION, GENETIC MUTATION NEOPLASMS