Author/Editor		Grobovšek-Opara, Sonja; Kožuh-Novak, Mateja; Križman, Igor
Title		Vpliv alkoholnih pijač, prehrane in zdravil na tveganje zbolevanja za jetrno cirozo
Translated title		Influence of alcohol consumption, diet and drugs on the risk for liver cirrhosis occurrence
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 67, št. 12
Publication year		1998
Volume		str. 727-32
Language		slo
Abstract		Background. Our research is a case-control study where the influence of alcohol drinking, diet and drugs consumption on the risk of liver cirrhosis occurrence in Slovenia was investigated. Methods. 182 in-patients were included in the study, who were for the first time treated for liver cirrhosis on the internal disease wards of the Slovenian hospitals in the period between January to July 1995. Liver cirrhosis was diagnosed on the basis of clinical status, laboratory tests and liver ultrasound examination. Control persons were taken from the Population registry of the Statistical Offic of the Republic of Slovenia, and they were adjusted to the patients according to gender, age and dwelling place. We searched for two control persons for each patient. The data were gathered in personal interviews. Patients were interviewed in hospitals and control persons at their homes. In the statistical analysis of data the univariate and multivariate conditional logistic regression was used. Results. We found out that consuming alcohol and hepatoxic drugs increased the risk for liver cirrhosis, while the appropriate diet had a protective effect. The association between the alcohol drinking and liver cirrhosis depends on the daily amount of consumed alcohol and the duration of drinking; the risk for liver cirrhosis was growing with increasing cumulative amount of alcohol. Calculated odds rations were high, confirming the causal relatioship between alcohol drinking and liver cirrhosis occurrence. Alcohol drinkers had 7.3-times greater risk for liver cirrhosis appearance in comparison with non-drinkers. The border for the risk for liver cirrhosis to increase significantly was 250 kg of pure alcohol consumed during life-time or average daily intake of 20 g of pure alchol.(Abstract truncated at 2000 characters)
Summary		Izhodišča. Raziskava je študija primerov s kontrolami, v kateri smo ugotavljali vpliv alkoholnih pijač, prehrane in zdravil na tveganje zbolevanja za jetrno cirozo v Sloveniji. Metode. V raziskavo smo zajeli 182 bolnikov, ki so se v času od januarja do julija 1995 prvič zdravili zaradi jetrne ciroze na internih oddelkih slovenskih bolnišnic in pri katerih je bila jetrna ciroza ugotovljena na osnovi klinične slike, ustreznih laboratorijskih izvidov in ultrazvočne preiskave. Kontrolne osebe smo poiskali po podatkih iz Registra prebivalcev Statističnega urada RS in so bile usklajene z bolniki po spolu, starosti in kraju stalnega bivališča. Za vsakega bolnika smo poiskali po dve kontrolni osebi. Podatke smo zbrali z osebnim intervjujem. Bolnike smo anketirali v bolnišnicah, kontrolne osebe pa na njihovem domu. V statistični obdelavi podatkov smo uporabili univariatno in multivariatno pogojno logistično regresijo. Rezultati. Ugotovili smo, da pitje alkoholnih pijač in uživanje hepatotoksičnih zdravil povečata tveganje za nastanek jetrne ciroze, ustrezna prehrana pa deluje zaščitno. Povezanost med alkoholom in jetrno cirozo je odvisna od dnevne količine popite alkoholne pijače in trajanja pitja; tveganje za jetrno cirozo se je s kumulativno količino alkohola večalo. Izračunana razmerja obetov so bila visoka, kar potrjuje ze znano vzročno povezanost pitja alkoholnih pijač z nastankom jetrne ciroze. Pivci alkoholnih pijač so imeli 7,3-krat večje tveganje za nastanek jetrne ciroze v primerjavi z nepivci. Meja, kjer se je tveganje za jetrno cirozo zanesljivo povečalo, je bila pri zaužiti življenjski količini 250 kg čistega alkohola ali pri povprečnem dnevnem vnosu 20 g čistega alkohola. Kot zaščitna se je izkazala prehrana z veliko ogljikovih hidratov in maščob.(Izvleček prekinjen pri 2000 znakih)
Descriptors		LIVER CIRRHOSIS ALCOHOL DETERRENTS DIET CASE-CONTROL STUDIES HOSPITALIZATION RISK FACTORS DRUGS NUTRITIVE VALUE ENERGY METABOLISM