Author/Editor		Jurčić, Vesna
Title		Adhesion molecules in acute and chronic rejection
Type		članek
Source		In: Pajer Z, Štiblar-Martinčič D, editors. International symposium on cardiovascular diseases. Proceedings of the 29th memorial meeting devoted to prof. dr. Janez Plečnik; 1998 Dec 3-5; Ljubljana. Ljubljana: Medical faculty, Institute of histology and embryology,
Publication year		1998
Volume		str. 295-8
Language		eng
Abstract		The author investigated the expression of cellular adhesion molecules (CAMs) ICAM-1, VCAM-1, PECAM and E-selectin as well as HLA-DR and IL2-R in different vascular segments of nephrectomy specimens in kidney allografts with acute and chronic rejection. In acute rejection, ICAM-1, VCAM-1 and HLA-DR were strongly upregulated on endothelium in different vascular segments, which is probably important in mononuclear cell infiltration of the interstitium and vessels, as a part of cellular immune mechanisms. This is also supported by finding of IL2-R positive activated mononuclear inflammatory cells. A positivity for E-selection was focal, probably due to its transient expression. In chronic rejection, ICAM-1, VCAM-1 and HLA-DR were also found to be upregulated in different vascular segments, but less intensive and focal, with the exception of peritubular capillaries. It is probably related to the regular presence of interstitial cell infiltrate inchronic rejection, while arteries and veins, differently from the acute rejection, usually do not show prominent exudative changes. furthermore, IL2-R and E-selectin positivity was not present in chronic rejection. These findings are in accordance with the general oppinion that the pathogenesis immune and nonimmune factors are involved. Our results do not explain the segmental differences inthe histopathology of kidney vessels in acute and chronic rejection, such as more prominent cell infiltration and less intensive insudative changes of arteries compared to arteroles.
Descriptors		KIDNEY TRANSPLANTATION GRAFT OCCLUSION, VASCULAR CELL ADHESION MOLECULES GRAFT REJECTION HLA-DR ANTIGENS ANTIGENS, CD31 INTERLEUKIN-2