Author/Editor		Štiblar-Martinčič, Draga
Title		Cell death via apoptosis
Type		članek
Source		In: Pajer Z, Štiblar-Martinčič D, editors. International symposium on cardiovascular diseases. Proceedings of the 29th memorial meeting devoted to prof. dr. Janez Plečnik; 1998 Dec 3-5; Ljubljana. Ljubljana: Medical faculty, Institute of histology and embryology,
Publication year		1998
Volume		str. 355-62
Language		eng
Abstract		Apoptosis, named also programmed cell death, represents one form of cell dealth and has a crucial role in the tissue homeostasis. Besides this, apoptosis is involved in a number of pathological conditions, such as cancer, autoimmune diseases and viral infections. Morphological characteristics of apoptosis are cell shrinkage, chromatin condensation, membrane blebbing and formation of apoptotic bodies. Apoptosis is genetically regulated process of cell death with biochemical feature of enzymes activation, involving cleavage of nuclear DNA by endonuclease, translocation of plasma membrane phosphatidylserine, triggering and initiation the apoptosis by activation of cytoplasmic proteinases and responsibility of tranglutaminase for formation of apoptotic bodies. Apoptosis is an active, progressive and genetically regulated process in which different family of genes are involved among which the bcl-2, c-myc, p53 and APO-1/Fas are better understood by now. In multicellular organisms apoptosis serves as a clean and efficient mechanism for the elimination of unwanted cells, that may have been damaged, produced in excess or whose function is no longer required.
Descriptors		APOPTOSIS NECROSIS CELL DEATH