Author/Editor		Rus, Barbara; Zorc, Metka; Petrovič, Danijel
Title		Apoptosis and atherosclerosis
Type		članek
Source		In: Pajer Z, Štiblar-Martinčič D, editors. International symposium on cardiovascular diseases. Proceedings of the 29th memorial meeting devoted to prof. dr. Janez Plečnik; 1998 Dec 3-5; Ljubljana. Ljubljana: Medical faculty, Institute of histology and embryology,
Publication year		1998
Volume		str. 379-83
Language		eng
Abstract		Vascular endothelial injury, which is a critical initiating event in atherogenesis, results in atherosclerotic plaques in few decades. Apoptotic process has an important role in plaque evolution. Apoptosis of smooth muscle cells in the shoulder region of the plaque may lead to plaque destabilization. On the contrary, apoptosis of the macrophages in the same region favors plaque stability. Factors that induce apoptotic cell death in human atherosclerotic plaques are largely unknown. In a diffuse and distal coronary artery disease mostly sclerotic and calcified lesions with only few foci of cellular elements are present, and the predominant cell type in the mononuclear infiltrates are macrophages. Different modalities such as beta-irradiation can be used for modification of apoptotic process in atherosclerosis.
Descriptors		CORONARY ARTERIOSCLEROSIS APOPTOSIS MYOCARDIUM DNA NUCLEOTIDYLEXOTRANSFERASE